Methods and apparatus are disclosed for using a programmable lookup word generator to produce a lookup word for use by a content-addressable memory. The programmable lookup word generator includes a profile memory which contains instructions on how to build a particular lookup word. The programmable lookup word generator receives a set of information and possibly other operands typically including a profile selection. Based on the profile selection, a set of instructions is retrieved from the profile memory. Control logic uses this set of instructions to build the lookup word by extracting portions of the received information and other operands and ordering these extracted portions possibly with additional information to build the lookup word. The lookup word is then used by a CAM, typically to classify the received set of information and other operands. In one context, the CAM produces a packet classification indication in a communication or computer system.