A novel soybean cultivar, designated SO22207, is disclosed. The invention relates to the seeds of soybean cultivar SO22207, to the plants of soybean SO22207 and to methods for producing a soybean plant produced by crossing the cultivar SO22207 with itself or another soybean variety. The invention further relates to hybrid soybean seeds and plants produced by crossing the cultivar SO22207 with another soybean cultivar.