The invention provides methods and compositions for inducing and detecting
signal transduction through LDL receptors, including specifically
detecting a stress that alters a functional interaction of a low density
lipoprotein (LDL) receptor binding polypeptide with an LDL receptor
interaction domain, by (a) introducing a predetermined stress into a
system which provides a physical interaction of an LDL receptor binding
polypeptide with an LDL receptor intracellular binding polypeptide
interaction domain, whereby the system provides a stress-biased
interaction of the binding polypeptide and the interaction domain,
wherein the absence of the stress, the system provides a unbiased
interaction of the binding polypeptide and the interaction domain; and
(b) detecting the stress-biased interaction of the binding polypeptide
and the interaction domain, wherein the binding polypeptide is selected
from SEMCAP-1, JIP-1, PSD-95, JIP-2, Talin, OMP25, CAPON, PIP4,5 kinase,
Na channel brain 3, Mint1, ICAP-1 and APC subunit 10.