A CPU selectively programs one or more graphics devices by writing a control command to the command buffer that designates a subset of graphics devices to execute subsequent commands. Graphics devices not designated by the control command will ignore the subsequent commands until re-enabled by the CPU. The non-designated graphics devices will continue to read from the command buffer to maintain synchronization. Subsequent control commands can designate different subsets of graphics devices to execute further subsequent commands. Graphics devices include graphics processing units and graphics coprocessors. A unique identifier is associated with each of the graphics devices. The control command designates a subset of graphics devices according to their respective unique identifiers. The control command includes a number of bits. Each bit is associated with one of the unique identifiers and designates the inclusion of one of the graphics devices in the first subset of graphics devices.