Polyacetals comprising a recurring units represented by a formula selected
from the group consisting of formula (I) and (II):
##STR1##
- wherein A comprises at least one acetal group; B is selected from the
group consisting of —CH—, —CH(CH3)—, CH2CH—,
—CH2C(CH3)—, —CH(CH3)CH—,
and —CHCH(CH3)CH(CH3)—; Z is selected from the
group consisting of C(O)OR1, C(O)SR1, C(O)NR1R2,
and VU; V is a linker group; U is selected from the group consisting of poly(ethyleneimine),
poly(propyleneimine), poly(lysine), PAMAM dendrimer, octaamine dendrimer, hexadecaamine
dendrimer, enhancer, and targeting receptor; R1 and R2 are
each individually selected from the group consisting of hydrogen, C1
to C10 alkyl, and C6 to C10 aryl; D is a linkage
selected from the group consisting of carboxylic amide, carboxylic ester, urea,
and urethane; and G is selected from the group consisting of C4 to C20
alkyl, C6-C10 aryl, and —(OCH2CH2)n—,
where n is in the range of 1 to about 250, are useful in nucleic acid delivery
applications. In preferred embodiments, complexes formed between polyacetals of
the formulae (I) or (II) and polynucleotides are useful as transfection reagents.
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