A sustained-release preparation which comprises a physiologically active peptide of general formula ##STR1##

wherein X represents an acyl group;

  • R1, R2 and R4 each represents an aromatic cyclic group;
  • R3 represents a D-amino acid residue or a group of the formula
  • ##STR2##

    wherein R3 is a heterocyclic group;

  • R5 represents a group of the formula —(CH2)n—R5 wherein n is 2 or 3, and R5 is an amino group which may optionally be substituted, an aromatic cyclic group or an O-glycosyl group;
  • R6 represents a group of the formula —(CH2)n—R6 wherein n is 2 or 3, and R6 is an amino group which may optionally be substituted;
  • R7 represents a D-amino acid residue or an azaglycyl residue; and
  • Q represents hydrogen or a lower alkyl group, or a salt thereof and a biodegradable polymer having a terminal carboxyl group.
  • The sustained-release preparation shows a constant release of the peptide over a long time and is substantially free from an initial burst.

     
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