The invention provides methods and compositions relating to an IB kinase,
IKK-, and related nucleic acids. The polypeptides may be produced recombinantly
from transformed host cells from the disclosed IKK- encoding nucleic acids
or purified from human cells. The invention provides isolated IKK- hybridization
probes and primers capable of specifically hybridizing with the disclosed IKK-
genes, IKK--specific binding agents such as specific antibodies, and methods
of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.