The present invention relates to molecular constructs and methods of their use
in detecting biochemical reactions. In particular, the invention relates to a molecular
construct having a capture portion and a substrate portion, where the capture portion
isolates the construct from a sample medium, and the substrate portion enables
the construct to be acted upon and undergo a physical change which can be detected
and measured. These molecular constructs may be used in diagnostic assays, genetic
screening for potential risks of certain diseases in individuals, and drug discovery
and toxicogenomics, using high throughput screening of compounds.