The present disclosure relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present disclosure provides transgenic mice comprising mutations in a .beta.3GalT2 gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

 
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< Animal models of cancer development and metastasis

< Transgenic mice containing TMEM3 beta-1,3-N-acetylglucosaminyltransferase gene disruptions

> Modification of plant lignin content

> Transgenic pigs carrying both hHO-1 and hDAF transgenes for xenotransplantation

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