The present invention relates generally to compounds that inhibit serine proteases.
In particular it is directed to novel amino-bicyclic pyrazinone and pyridinone
compounds of Formula (I):
##STR1##
or a stereoisomer or pharmaceutically acceptable salt form thereof, which are
useful as selective inhibitors of serine protease enzymes of the coagulation cascade;
for example thrombin, factor Xa, factor XIa, factor IXa, and/or factor VIIa. In
particular, it relates to compounds that are factor VIIa inhibitors. This invention
also relates to pharmaceutical compositions comprising these compounds and methods
of using the same.