Disclosed are methods of conjugating biologically active substances, particularly, alpha-interferon, with a hyaluronan or a mixture of a hyaluronan with at least one other hydrophilic polymer having a functional group capable of reacting with divinyl sulfone. Also disclosed are stable intermediates formed by partially reacting a hyaluronan with divinyl sulfone and stopping the reaction before completion to leave free, or reactive vinyl groups on the hyaluronan molecule available for conjugation with the biologically active substance.

 
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< Substituted cyclohexane derivatives

< Anti-mesothelin antibodies having high binding affinity

> Oligonucleotide analogues

> Pharmaceutical compositions comprising 1-isopropyl-3-[(4-m-toluidino-3-pyridyl)sulphonyl]-urea as active ingredient

~ 00256