A universal power measurement SoC includes an analog signal conditioning circuit, analog-to-digital converter circuit, memory and micro control unit. The analog signal conditioning circuit receives physical signals from a signal sensor and adjusts the polarities and amplitudes of the signals to produce suitable analog signals and gain status. The analog-to-digital converter circuit converts the adjusted analog signals into digital signals. The memory stores the pre-setup parameters of the power measurement. The micro control unit, according to users' choices, processes the converted digital signals with the gain status to produce the output signals of the power measurement.