A door opening trim weather strip for a motor vehicle, which exhibits excellent noise insulating properties between a door opening portion of a vehicle body and a door of a motor vehicle, and requires a small force for closing the door, thereby improving feelings in closing the door. The door opening trim weather strip includes a trim portion in which a flange provided in the door opening portion is adapted to be inserted, and a tubular seal portion for sealing between the door opening portion and the door. The tubular seal portion includes two base parts which are respectively composed of a solid rubber and project from an outside surface of an outer side wall of the trim portion integrally therewith, an arc-shaped part which is composed of a sponge rubber and of which ends are respectively connected to the two base parts to form a generally arc-shaped cross-section, and a noise insulating wall which is composed of a sponge rubber and is formed in a space defined by the outer side wall, the two base parts and the arc-shaped part into a generally inverted v-shaped cross-section. The noise insulating wall has a bending part at about a widthwise center thereof. Ends of the noise insulating wall are respectively connected to an inside surface of the arc-shaped part such that at least one portion of the noise insulating wall is foldable between the two base parts.