The present invention provides means to improve the chemical stability of aqueous,
parenteral pharmaceutical compositions comprising a polypeptide and glycerin. Reactive
aldehydes are identified in commercial glycerins, and means for reducing such are
provided. Convenient means are provided to assay for reactive aldehydes in glycerin,
and a strong linear correlation between the level of reactive aldehydes in glycerin
and chemical stability of compositions comprising a polypeptide and glycerin is
demonstrated. The invention includes aqueous compositions comprising a polypeptide
and glycerin having improved chemical stability compared to compositions previously known.