Pharmaceutical compositions and compounds are provided. The compounds
of the invention have anti-proliferative activity, and may promote apoptosis in
cells lacking normal regulation of cell cycle and death. In one embodiment of the
invention, formulations of the compounds in combination with a physiologically
acceptable carrier are provided. The pharmaceutical formulations are useful in
the treatment of hyperproliferative disorders, which disorders include tumor growth,
lymphoproliferative diseases, angiogenesis. The compounds of the invention are
1,2,3-thiadiazoles having the structure:
##STR1##
and including stereoisomers, solvates, and pharmaceutically acceptable salts
thereof, wherein each of R1, R22 , R3 and R4
is independently selected from hydrogen, R5R6, and
R7, R5 is selected from alkyl, heteroalkyl, aryl and heteroaryl;
R6 is selected from (R5)n-alkylene, (R5)n-heteroalkylene,
(R5)n-arylene and (R5)n-heteroarylene;
R7 is selected from (R6)n-alkylene, (R6)n-heteroalkylene,
(R6)n-arylene, and (R6)n-heteroarylene;
and n is selected from 0, 1, 2, 3, 4 and 5, where R1 and R2 may
together form a heterocyclic structure including the nitrogen to which they are
both attached, and R3 and R4 may together form a heterocyclic
structure including the nitrogen to which they are both attached; and each of L1
and L2 is independently selected from -A1-A2-A3- where each of
Al, A2, and A3 is independently selected from a direct bond, alkylene, heteroalkylene,
arylene and heteroarylene.
