Antisense compounds, compositions and methods are provided for modulating
the expression of matrix metalloproteinase 1. The compositions comprise
antisense compounds, particularly antisense oligonucleotides, targeted to
nucleic acids encoding matrix metalloproteinase 1. Methods of using these
compounds for modulation of matrix metalloproteinase 1 expression and for
treatment of diseases associated with expression of matrix
metalloproteinase 1 are provided.