GnRH receptor antagonists are disclosed that have utility in the treatment of
a variety of sex-hormone related conditions in both men and women. The compounds
of this invention have the structure:
##STR1##
wherein n, R1a, R1b, R1c, R2a,
R2b, R3, R4, R5, R6 and
X are as defined herein, including stereoisomers, prodrugs and pharmaceutically
acceptable salts thereof. Also disclosed are compositions containing a compound
of this invention in combination with a pharmaceutically acceptable carrier, as
well as methods relating to the use thereof for antagonizing gonadotropin-releasing
hormone in a subject in need thereof.
