An information processing system includes three storage apparatuses installed on three sites for the purpose of disaster recovery. The three storage apparatuses can be accessed by three information processing apparatuses, respectively, that are configured in a cluster. One of the storage apparatuses is set as a replication source and the other two storage apparatuses are set as replication destinations. The two storage apparatuses that are set as replication destinations manage a copy of data stored in the storage apparatus that is set as the replication source. In association with an execution of a failover on the information processing apparatus side, settings of the storage apparatuses as the replication source and replication destinations are automatically changed such that the storage apparatus that is set as the replication source function as a replication destination, and one of the storage apparatuses that are set as the replication destinations function as a replication source.