Conformationally constrained compounds which mimic the secondary
structure of reverse-turn regions of biologically active peptides and proteins
having the following structure are disclosed:
##STR1##
wherein A, B, X, R1, and R5 are as defined herein.
Such compounds have utility over a wide range of fields, including use as diagnostic
and therapeutic agents. In particular, compounds of this invention are useful in
pharmaceutical compositions as anti-inflammatory agents as well as inhibitors of
central nervous disorders. Libraries containing the compounds of this invention
are also disclosed, as well as methods for screening the same to identify biologically
active members.
