The present invention relates to new substituted aryl and heteroaryl derivatives of general formula ##STR1##

wherein

• A, Ar, n, X, Y₁, Y₂, Y₃, Y₄, R₁ and R₅ are defined as in claim 1, the prodrugs, the tautomers, stereoisomers, mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable properties. Thus, the compounds of the above general formula I wherein R₅ does not contain a cyano group have, in particular, an antithrombotic effect and a selective factor Xa-inhibiting effect with generally improved compatibility. The compounds of the above general formula I wherein R₅ contains a cyano group are valuable intermediate products for preparing the antithrombotic compounds of general formula I.