The present invention features compounds useful for inhibiting RNase P activity. These compounds can be used as therapeutics for treating or preventing a variety of bacterial infections. The compounds belong to several classes including mono- and bis-guanylhydrazones, guanylhydrazone mimetics, and benzothiazolium compounds. Exemplary compounds are compounds of formula I:

Y—(NR)k—U1—(NR")I—A—(NR1)m—U2—(NR2)n—Z  I

with substituents as described herein.

 
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