A method of dusting-preventive treatment in which a powder having dusting property is treated with fibril-forming PTFE (polytetrafluoroethylene) to impart non-dusting property thereto and the non-dusting property of the powder, after having been reduced during transportation, are economically and advantageously recovered or improved through a relatively simple step. The method comprises: a first dusting-preventive treatment step in which fibril-forming polytetrafluoroethylene is added to a powder having dusting property, and a compression/shear force is exerted to the mixture at a temperature in the range of 20 to 200 C. to thereby regulate powder so as to have a flow value of 150 mm to 200 mm; and a second dusting-preventive treatment step in which a compression/shear force is exerted again at a temperature in the range of 50 to 150 C., without newly adding fibril-forming polytetrafluoroethylene, to the resultant powder after the powder treated in the first step has deteriorated in dusting-preventive property during transportation with transporting means due to such an external force that the polytetrafluoroethylene fibrils partly cleave or powder particles partly fall off polytetrafluoroethylene fibril nets.