These objects and others may be accomplished with the present invention, the
first embodiment of which provides an oil-in-water nanoemulsion, which includes:
- an oily phase dispersed in an aqueous phase;
- (i) at least one amphiphilic lipid selected from the group including
nonionic amphiphilic lipids, anionic amphiphilic lipids, and combinations thereof; and
- (ii) at least one water-soluble nonionic polymer selected from the group
including homopolymers and copolymers of ethylene oxide; polyvinyl alcohols; homopolymers
and copolymers of vinylpyrrolidone; homopolymers and copolymers of vinylcaprolactam;
homopolymers and copolymers of polyvinyl methyl ether; neutral acrylic homopolymers
and copolymers; C1-C2 alkyl celluloses and their derivatives;
C1-C3 alkyl guar; C1-C3 hydroxyalkyl
guar; and combinations thereof;
- wherein a ratio of the weight of the oily phase to the weight of the
amphiphilic lipid (i) ranges from 1.2 to 10;
and wherein the oily phase includes oil globules having a number-average size
of less than 100 nm. The nanoemulsion obtained is preferably transparent and stable
on storage. It may form a composition for topical, preferably cosmetic or dermatological
compositions, pharmaceutical compositions and ophthalmological compositions.
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