The present invention is a system and method for anticipating potential Adverse Drug Events (ADE) in a patient's medication regimen by integrating data typically located in laboratory and pharmacy information systems and filtering the data using predefined criteria. The present invention includes a system for anticipating a possible ADE through the use of a search engine that compares integrated data from laboratory and pharmacy information systems and compares it to predefined ADE rules defining normal ranges for a particular laboratory test. If an abnormal test value is received and a drug in the patient's medication regimen satisfies a drug included in an ADE rule then an alert procedure is triggered which allows for a period of time wherein the patient's lab and pharmacy data is monitored in order to determine if a proper corrective action is undertaken, and if no corrective action or an improper corrective action is taken within that period of time, the healthcare provider is warned of a potential ADE.