A system, computer program product and method of preventing and controlling sulfide mineral oxidation and generation of acid rock drainage in a mass of sulfidic waste is provided. The mass of sulfidic waste includes a cover. The method involves applying under the cover of an oxygen deficient/non-reactive gas mixture, substantially throughout the mass of sulfidic waste, in a quantity sufficient to create a pressure differential between the inside of the mass of sulfidic waste and the open atmosphere outside and adjacent to the mass of sulfidic waste, such that the oxygen gas concentration inside the mass of sulfidic waste is substantially equal to, or less than, the atmospheric oxygen gas concentration outside and adjacent to the mass of sulfidic waste. The system includes a distribution system and sensors for detecting acid rock drainage conditions of the mass of sulfidic waste, and in response applying an effective amount of oxygen deficient/non-reactive gas mixture. The computer program product consists of a control program for directing a computer to activate the distribution system to prevent and control acid rock drainage in a mass of sulfidic waste in accordance with the method.