The invention relates to methods and products for inducing IL-10 expression using immunostimulatory nucleic acids. In particular, the invention relates to methods and products for inducing IL-10 expression without inducing high levels of IFN-.alpha. expression. IL-10-inducing immunostimulatory nucleic acids preferably include a TC dinucleotide at the 5' end and a CG dinucleotide towards the 3' end, but not near the 5' end. The invention is useful for treating and preventing disorders associated with a Th1 or Th2 immune response or for promoting a T regulatory cell environment suitable for suppressing inappropriate immune responses (e.g., for controlling or suppressing excessive immune responses).

 
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< Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends

< Drug-carrier complexes and methods of use thereof

> Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides

> Immunostimulatory oligonucleotide multimers

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