A series of N-alkanol-N-phenyl benzenesulfonamide and related derivatives of the Formula I are disclosed, ##STR1##

wherein R1, R2, R3, X, and Y are defined herein. The compounds are inhibitors of -amyloid peptide (-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions characterized by aberrant extracellular deposition of amyloid. Pharmaceutical compositions and methods of treatment are also disclosed.

 
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