A system and method of diagnostic imaging is provided that includes positioning a subject in an imaging device, performing at least one scout scan, and marking a user-defined region-of-interest. An attenuation characteristic of an attenuation filter is then automatically adjusted based on the user-defined region-of-interest. The present invention automatically selects a proper attenuation filter configuration, corrects patient centering, and corrects noise prediction errors, thereby increasing dose efficiency and tube output.