Sequence data for the sheep .alpha.(1,3)galactosyltransferase (.alpha.1,3GT) gene is provided in this disclosure, which allows the user to construct vectors for expressing or inactivating the .alpha.1,3GT gene. This in turn enables the user to control expression of the Gal.alpha.(1,3)Gal xenoantigen on the surface of cells.

 
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> Transgenic non-human animals for producing chimeric antibodies

> Human artificial chromosome containing human antibody lambda light chain gene and non-human animal containing the human artificial chromosome capable of genetic transmission

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