A wireless, programmable system for bio-potential signal acquisition (e.g., electrocardiogram (ECG) data) includes a base unit and a plurality of individual wireless, remotely programmable transceivers that connect to patch electrodes. The base unit manages the transceivers by issuing registration, configuration, data acquisition, and transmission commands using wireless techniques. Bio-potential signals from the wireless transceivers are demultiplexed and supplied via a standard interface to a conventional monitor for display.