The invention concerns the manufacture of an antibiotic coating of elements with interconnecting microcavities, elements thus coated as well as their use. In a preferred embodiment, a homogenous solution of a gentamicin derivative in a solvent is introduced into the microcavities of non-metallic elements with interconnecting microcavities through dipping, spraying and dripping, and following evaporation or vaporization of the solvent, a layer of the gentamicin derivative is formed on the surface of the microcavities.