The invention provides truncated biologically active ADAMTS polypeptides, particularly those with hyalectenase activity, and more particularly those with aggrecanase activity, that exhibit greater stability and homogeneity and higher expression yields than their full-length counterparts. The invention also provides nucleic acid molecules encoding such truncated biologically active ADAMTS polypeptides and methods for producing the truncated biologically active ADAMTS polypeptides. In addition, the invention provides methods for identifying compounds capable of modulating biologically active ADAMTS polypeptides, particularly those compounds that inhibit aggrecanase activity.

 
Web www.patentalert.com

< Mipp1 homologous nucleic acids and proteins involved in the regulation of energy homeostatis

< Recombinant vectors for use in position-independent transgene expression within chromatin

> Human and mouse beta-defensins, antimicrobial peptides

> Therapeutic compositions and methods for treating diseases that involve angiogenesis

~ 00227