The present invention provides benzamide inhibitors of the P2X7 receptor
of the formula:
##STR1##
wherein R1-R3 are as defined herein. The compounds
of the invention are useful in the treatment of IL-1 mediated disorders, including,
without limitation, inflammatory diseases such as osteoarthritis and rheumatoid
arthritis; allergies, asthma, COPD, cancer, reperfusion or ischemia in stroke or
heart attack, autoimmune diseases and other disorders.
