Amplibody compositions and methods used to interact with agglomeration proteins and initiate and mediate an aggregation cascade are disclosed herein. Compositions herein comprise one or more DNA or RNA molecules having affinity for at least one agglomeration protein. The nucleic acid component is a naturally occurring or non-naturally occurring molecule with twenty or more ribonucleotide bases. For RNA, at least one nucleotide sequence portion of this RNA molecule has affinity to at least one consensus sequence present in the agglomeration RNA-binding protein. The isolated RNA molecules of the present invention bind agglomeration proteins to initiate and mediate the progression of a nucleo-protein aggregation cascade. The nucleo-protein aggregation cascade can be self-catalyzing, with formation of intermediate aggregates comprising an RNA molecule and one or more agglomeration proteins.