A method of measuring an analyte using a dry analytical element which comprises,

• a process of supplying a measuring reagent solution to the anlaytical element comprising at least a hydrophilic polymer layer and a microporous layer having a surface rendered hydrophilic and having a blood cell-separating ability laminated onto a water-impermeable support and not containing the measuring reagents to which a liquid sample has been supplied and thereby reaction occuring, and
• a process of measuring the analytical element wherein the reaction occurred by an optical means. According the above method, the shelf life of the analytical element is greatly improved. Besides, since the measuring reagnts used in the conventional wet analysis can be used, it is not necessary to develop analytical elements for each measuring item. Moreover, one kind of analytical element can be applied to many items.