The present invention provides a multi-piece solid golf ball, which is superior in flight distance, spin performance, shot feel and putting sound. The present invention relates to a multi-piece solid golf ball comprising a core consisting of a center, an intermediate layer formed on the center and an outer layer formed on the intermediate layer, and a cover covering the core, wherein the center has a diameter of 10 to 20 mm and a central point hardness in JIS-A hardness of 30 to 85, the intermediate layer has a surface hardness in Shore D hardness of 30 to 55, the outer layer has a hardness in Shore D hardness of 65 to 85 and comprises thermoplastic resin as a main component, and the cover has a Shore D hardness of 35 to 55 and a thickness of 0.3 to 1.5 mm.