An interference protection system for rejecting microwave or radio frequency interference signals is embedded into a sealed packaged chip at any port susceptible to being coupled to an interference signal such as I/O pins or antenna. The interference protection system includes a sense unit for detecting signals with amplitudes exceeding a predetermined threshold level and a protection unit including a pair of MOSFET switches connected in series and maintained in ON state during normal communication state. The switches are switched OFF once the sense unit detects the interference event. A registry unit is included for registering interference events.