A linear pixel-array processing systems uses a combination of digital and analog signal processing techniques to calibrate the gain and offset of each pixel in the analog domain. A plurality of fixed gain and offset values are applied in the analog domain to adjust the gain and offset of each pixel at high speeds (on the order of 25-50 MHz). By adjusting the gain and offset in the analog domain, the dynamic range of pixel conversion is improved such that the conversion range is fully utilized (over 90%, on the order of 95%-99%). The gain and offset values are determined with an algorithmic calibration routine that corrects for non-ideal effects in the signal path. A single processing channel can be multiplexed to process multiple pixel arrays to provide for a cost effective solution. In higher speed systems, the single processing channel can be extended to multiple processing channels for improved throughput.