9-Desoxoerythromycin compounds of formula I 1 wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are as defined herein, are useful as prokinetic agents for treating disorders of gastric motility.

 
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> RNA interference mediated inhibition of stearoyl-CoA desaturase (SCD) gene expression using short interfering nucleic acid (siNA)

> IRNA agents with biocleavable tethers

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