A self-vaccine as used herein will refer to methods of operating a disk drive and the apparatus implementing such methods, which make the disk drive immune to changes in temperature, that keep the disk drive healthy when hot or cold. The invention includes a self-vaccine extending the read channel optimization parameter database of a track zone or sequence to test temperature ranges actually found in the user's operation of the disk drive. The invention also includes the self-vaccine updating the read channel optimization parameter database for an already tested temperature range, whenever there has been sufficient time passed since the read channel optimization was performed for that temperature range. The invention includes read channel optimized parameters for at least temperature ranges within the embedded disk controller, which are updated in the user's operating environment during idle time providing the self-vaccine. The invention includes disk drives including a self-vaccine method.