A human stanniocalcin-alpha polypeptide and DNA (RNA) encoding such polypeptide
and a procedure for producing such polypeptide by recombinant techniques is disclosed.
Also disclosed are methods for utilizing such polypeptide for the regulation of
electrolyte imbalances which can lead to renal, bone and heart diseases and osteoporosis
and Paget's Disease. Antagonists against such polypeptides and their use in the
regulation of electrolyte imbalances which can lead to hypocalcemia and osteoporosis
are also disclosed. Use of the stanniocalcin-alpha sequence as a diagnostic to
detect diseases or the susceptibility to diseases related to a mutated form of
stanniocalcin-alpha sequences is also disclosed.