The present invention concerns processes for the preparation of each of the 4 diastereomers of formula (I) 1 in stereochemically pure form from either of two enantiomerically pure precursors. The tetracyclic ringsystem having trans-fused five and seven membered rings is formed in an acid-catalysed cyclization reaction. The invention further relates to the thus obtained cis-fused tetracyclic alcohol intermediates, the methanamine end-products, the methanamine end-products for use as a medicine, in particular as CNS active medicines.

 
Web www.patentalert.com

< 11-Beta hydroxysteroid dehydrogenase type 1 inhibitors as anti-obesity/anti-diabetes compounds and 17-beta hydrosteroid dehydrogenase type I inhibitors as useful agents for the treatment of cancers, especially breast cancer

< Substituted fused heterocyclic C-glycosides

> Ppar alpha selective compounds for the treatment of dyslipidemia and other lipid disorders

> Methods and devices for percutaneous, non-laparoscopic treatment of obesity

~ 00214