D type CpG oligodeoxynucleotides are provided herein that include a sequence represented by the following formula: 5' X.sub.1X.sub.2X.sub.3Pu.sub.1 Py.sub.2 CpG Pu.sub.3 Py.sub.4X.sub.4X.sub.5X.sub.6(W).sub.M(G).sub.N-3' wherein the central CpG motif is unmethylated, Pu is a purine nucleotide, Py is a pyrimidine nucleotide, X and W are any nucleotide, M is any integer from 0 to 10, and N is any integer from 4 to 10. Methods of using these oligodeoxynucleotides to induce an immune response are provided.

 
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