One aspect of the present invention relates to novel heterocyclic compounds comprising
urea functionality. A second aspect of the present invention relates to the use
of the novel heterocyclic compounds comprising urea functionality as ligands for
various cellular receptors, including opioid receptors, other G-protein-coupled
receptors and ion channels. An additional aspect of the present invention relates
to the use of the novel heterocyclic compounds comprising urea functionality as analgesics.