An optical sampling interface system is disclosed that minimizes and compensates for errors that result from sampling variations and measurement site state fluctuations. Embodiments of the invention use a guide that does at least one of, induce the formation of a tissue meniscus, minimize interference due to surface irregularities, control variation in the volume of tissue sampled, use a two-part guide system, use a guide that controls rotation of a sample probe and allows z-axis movement of the probe, use a separate base module and sample module in conjunction with a guide, and use a guide that controls rotation. Optional components include an occlusive element and a coupling fluid.

 
Web www.patentalert.com

< Method and apparatus for using alternative site glucose determinations to calibrate and maintain noninvasive and implantable analyzers

< Antagonists for treatment of CD/11CD18 adhesion receptor mediated disorders

> Method and apparatus for using alternative site glucose determinations to calibrate and maintain noninvasive and implantable analyzers

> Neurological event monitoring and therapy systems and related methods

~ 00208