A method for improving bacteria and reagent actions on mineral-bearing particles. In the heap leaching process, the method also increases percolation of the leach solution through the heaped ore without the use of high concentrations of cement, high concentrations of high molecular weight polymers, or high concentration of any other binding agents. The method is accomplished by a process comprising the applying of solutions of varying combinations of bacteria, bacterial nutrients, or leaching reagents, together with surface acting agents onto the ore particles before the ore is formed into a heap. The reagents are applied by spray or foggers or foam into the ore as the ore is mined, transported out of the mine, crushed, or transferred to the heap, and before it is formed into the heap.