The present invention relates to a structure comprising a biological membrane
and a porous or perforated substrate, a biological membrane, a substrate, a high
throughput screen, methods for production of the structure membrane and substrate,
and a method for screening a large number of test compounds in a short period.
More particularly it relates to a structure comprising a biological membrane adhered
to a porous or perforated substrate, a biological membrane capable of adhering
with high resistance seals to a substrate such as perforated glass and the ability
to form sheets having predominantly an ion channel or transporter of interest,
a high throughput screen for determining the effect of test compounds on ion channel
or transporter activity, methods for manufacture of the structure, membrane and
substrate, and a method for monitoring ion channel or transporter activity in a membrane.