The invention encompasses a compositions of at least one statin, at least
one pharmaceutically acceptable solvent, and at least one surface active
agent. In the composition, about 9% to about 50% by weight of the statin
is hydrolyzed from a closed lactone form to an open hydroxy acid form
when the composition is placed in an aqueous acidic solution. The
invention also encompasses method of making the composition and methods
of treating high cholesterol, multiple sclerosis, and/or Alzheimer's
disease using the compositions described herein.