Polysubstituted catechol-based universal solid supports suitable for synthesizing oligonucleotides have been prepared. Following synthesis, cleavage of the oligonucleotide from the solid support and catechol-assisted elimination of the 3'-phosphate group is accomplished by treatment with standard basic media such as ammonium hydroxyde or.sup.1 methylamine.

 
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> Modified polypeptides stabilized in a desired conformation and methods for producing same

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