The biological effects of the cytokine TNF are mediated by binding to receptors on the surface of cells. This disclosure describes new proteins and polynucleotides that promote enzymatic cleavage and release of TNF receptors. Also provided are methods for identifying additional compounds that influence TNF receptor shedding. As the active ingredient in a pharmaceutical composition, the products of this invention increase or decrease TNF signal transduction, thereby alleviating the pathology of disease.

 
Web www.patentalert.com

< Process for making a colored make-up cosmetic composition with controlled transmittance

< Compositions and methods for delivery of skin cosmeceuticals

> Systems and methods for topical treatment with nitric oxide

> Polymeric urethane ester tertiary amines and related personal care formulations

~ 00200